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Year : 2014  |  Volume : 20  |  Issue : 1  |  Page : 9-15

An insight in to Paget's disease of bone


1 Department of Oral Pathology and Microbiology, Bhojia Dental College and Hospital, Baddi, India
2 Department of Periodontology, DJ College of Dental Sciences and Research, Modinagar, Uttar Pradesh, India
3 Himachal Dental College and Hospital, Sundernagar, India
4 Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubneshwar, India
5 Department of Conservative Dentistry, Institute of Dental Sciences, Bhubneshwar, India
6 Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Bhubneshwar, India
7 Department of Oral Pathology and Microbiology, MMCDSR, Ambala, India

Correspondence Address:
Robin Sabharwal
Department of Oral Pathology and Microbiology, Bhojia Dental College and Hospital, Baddi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1117-6806.127098

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Paget's disease of bone (PDB) is a common disorder which may affect one or many bones. Although many patients are asymptomatic, a variety of symptoms and complications may occur. PDB is a focal disorder of bone turnover characterized by excessive bone resorption coupled with bone formation. PDB begins with a period of increased osteoclastic activity and bone resorption, followed by increased osteoblast production of woven bone that is poorly mineralized. In the final phase of the disease process, dense cortical and trabecular bone deposition predominates, but the bone is sclerotic and poorly organized and lacks the structural integrity and strength of normal bone. This article briefly reviews the etiopathogenesis, clinical radiographic and histological features of Paget's disease.


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