Nigerian Journal of Surgery

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 25  |  Issue : 1  |  Page : 21--25

Histopathological changes in gallbladder mucosa associated with cholelithiasis: A prospective study


Amandeep Singh, Guramritpal Singh, Kanwardeep Kaur, Gagandeep Goyal, Girish Saini, Deepika Sharma 
 Department of Surgery, GGS Medical College and Hospital, Faridkot, Punjab, India

Correspondence Address:
Dr. Amandeep Singh
Department of Surgery, GGS Medical College and Hospital, Faridkot, Punjab
India

Background and Aims: Cholelithiasis is known to produce diverse histopathological changes in the gallbladder mucosa. In the present study, we aimed to find the correlation between various gallstone characteristics (i.e., number, size, and morphological type) with the type of mucosal response in gallbladder mucosa (i.e., inflammation, hyperplasia, metaplasia, and carcinoma). Methods: The present study was conducted prospectively on 100 patients undergoing cholecystectomy for symptomatic cholecystitis. Gallstones were assessed for various parameters, i.e., number, size, and morphological type. Gallbladder mucosa was subjected to histopathological examination. Sections were taken from body, fundus, and neck of gallbladder. Results: Of 100 cases, maximum type was of mixed stones (54%) and was multiple in number (46%). However, gallstone type and number are nonsignificant variables to produce precancerous lesions (i.e., hyperplasia and metaplasia). Statistically significant results were obtained while comparing the mucosal response with gallstone size (P = 0.012). Conclusion: As the gallstone size increases, the response in gallbladder mucosa changes from cholecystitis, hyperplasia, and metaplasia to carcinoma. Gallstone type and number are nonsignificant variables to produce precancerous lesions.


How to cite this article:
Singh A, Singh G, Kaur K, Goyal G, Saini G, Sharma D. Histopathological changes in gallbladder mucosa associated with cholelithiasis: A prospective study.Niger J Surg 2019;25:21-25


How to cite this URL:
Singh A, Singh G, Kaur K, Goyal G, Saini G, Sharma D. Histopathological changes in gallbladder mucosa associated with cholelithiasis: A prospective study. Niger J Surg [serial online] 2019 [cited 2019 Sep 22 ];25:21-25
Available from: http://www.nigerianjsurg.com/article.asp?issn=1117-6806;year=2019;volume=25;issue=1;spage=21;epage=25;aulast=Singh;type=0